8GZ5

Crystal structure of neutralizing VHH P17 in complex with SARS-CoV-2 Alpha variant spike receptor-binding domain

Summary for 8GZ5

• Entry DOI: 10.2210/pdb8gz5/pdb
• Descriptor: Spike protein S1, Nanobody P17, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: sars-cov-2, spike rbd, nanobody, vhh, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 2
• Total formula weight: 38262.58

Authors

Yamaguchi, K.,Anzai, I.,Maeda, R.,Moriguchi, M.,Watanabe, T.,Imura, A.,Takaori-Kondo, A.,Inoue, T. (deposition date: 2022-09-25, release date: 2022-12-07, Last modification date: 2023-11-29)

• Primary citation: Yamaguchi, K.,Anzai, I.,Maeda, R.,Moriguchi, M.,Watanabe, T.,Imura, A.,Takaori-Kondo, A.,Inoue, T.; Structural insights into the rational design of a nanobody that binds with high affinity to the SARS-CoV-2 spike variant.; J.Biochem., 173:115-127, 2023; PubMed: 36413757; DOI: 10.1093/jb/mvac096

Experimental method

X-RAY DIFFRACTION (1.7 Å)