8GHP

GUCY2C-ECD bound to anti-GUCY2C-scFv antibody

Summary for 8GHP

• Entry DOI: 10.2210/pdb8ghp/pdb
• Descriptor: Guanylyl cyclase C, anti-GUCY2C-scFv antibody heavy chain, anti-GUCY2C-scFv antibody light chain, ... (4 entities in total)
• Functional Keywords: bi-specific antibody gucy2c antigen, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 74658.70

Authors

Mosyak, L. (deposition date: 2023-03-10, release date: 2023-08-30)

• Primary citation: Rampuria, P.,Mosyak, L.,Root, A.R.,Svenson, K.,Agostino, M.J.,LaVallie, E.R.; Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3.; Sci Rep, 13:13408-13408, 2023; PubMed: 37591971; DOI: 10.1038/s41598-023-40467-0

Experimental method

X-RAY DIFFRACTION (3.52 Å)