8G0H
Human PARP1 deltaV687-E688 bound to UKTT5 (compound 10) and to a DNA double strand break.
Summary for 8G0H
Entry DOI | 10.2210/pdb8g0h/pdb |
Related | 8FYY 8FYZ 8FZ1 |
Descriptor | DNA (5'-D(*CP*GP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*CP*G)-3'), Poly [ADP-ribose] polymerase 1, ... (6 entities in total) |
Functional Keywords | parp, adp-ribose transferase, dna break detection, zinc finger, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 183458.13 |
Authors | Rouleau-Turcotte, E.,Pascal, J.M. (deposition date: 2023-01-31, release date: 2024-02-07, Last modification date: 2024-03-27) |
Primary citation | Velagapudi, U.K.,Rouleau-Turcotte, E.,Billur, R.,Shao, X.,Patil, M.,Black, B.E.,Pascal, J.M.,Talele, T.T. Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem.J., 481:437-460, 2024 Cited by PubMed: 38372302DOI: 10.1042/BCJ20230406 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.8 Å) |
Structure validation
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