8FRJ

Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946

8FRJ の概要

• エントリーDOI: 10.2210/pdb8frj/pdb
• 分子名称: Transcription factor ETV6,Guanine-N7 methyltransferase nsp14 chimera, ZINC ION, 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (4 entities in total)
• 機能のキーワード: n7-guanine methyl transferase, sars-cov-2, nsp14, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36123.24

構造登録者

Kottur, J.,Aggarwal, A.K. (登録日: 2023-01-07, 公開日: 2023-07-26, 最終更新日: 2023-09-27)

• 主引用文献: Kottur, J.,White, K.M.,Rodriguez, M.L.,Rechkoblit, O.,Quintana-Feliciano, R.,Nayar, A.,Garcia-Sastre, A.,Aggarwal, A.K.; Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.; Plos Pathog., 19:e1011546-e1011546, 2023; PubMed: 37523415; DOI: 10.1371/journal.ppat.1011546

実験手法

X-RAY DIFFRACTION (1.57 Å)