8F0Q

Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310

Summary for 8F0Q

Entry DOI	10.2210/pdb8f0q/pdb
EMDB information	28777
Descriptor	Sodium channel protein PaFPC1,Sodium channel protein type 9 subunit alpha chimera, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose, ... (8 entities in total)
Functional Keywords	ion channel, small molecule, inhibitor, membrane protein-inhibitor complex, membrane protein/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	190603.53
Authors	Kschonsak, M.,Jao, C.C.,Arthur, C.P.,Rohou, A.L.,Bergeron, P.,Ortwine, D.,McKerall, S.J.,Hackos, D.H.,Deng, L.,Chen, J.,Sutherlin, D.,Dragovich, P.S.,Volgraf, M.,Wright, M.R.,Payandeh, J.,Ciferri, C.,Tellis, J.C. (deposition date: 2022-11-03, release date: 2023-04-12)
Primary citation	Kschonsak, M.,Jao, C.C.,Arthur, C.P.,Rohou, A.L.,Bergeron, P.,Ortwine, D.F.,McKerrall, S.J.,Hackos, D.H.,Deng, L.,Chen, J.,Li, T.,Dragovich, P.S.,Volgraf, M.,Wright, M.R.,Payandeh, J.,Ciferri, C.,Tellis, J.C. Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors. Elife, 12:-, 2023 Cited by PubMed: 36975198 DOI: 10.7554/eLife.84151 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation