8F0Q
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sodium channel protein PaFPC1,Sodium channel protein type 9 subunit alpha chimera | polymer | 1608 | 184481.9 | 1 | UniProt (D0E0C2) UniProt (Q15858) Pfam (PF00520) Pfam (PF08016) Pfam (PF16905) In PDB | Homo sapiens (human) | PaFPC1,NavPaS,Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7 |
2 | B | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB | |||
3 | A | beta-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (BMA) | |||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
5 | A | 5-cyclopropyl-4-({1-[(1S)-1-(3,5-dichlorophenyl)ethyl]piperidin-4-yl}methoxy)-2-fluoro-N-(methanesulfonyl)benzamide | non-polymer | 543.5 | 1 | Chemie (X7R) | |||
6 | A | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 5 | Chemie (PEE) | |||
7 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
8 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 1 - 1155 (UniProt: D0E0C2)
A: 1156 - 1285 (UniProt: Q15858)
A: 1286 - 1553 (UniProt: D0E0C2)
PDB | External Database | Details |
---|---|---|
Met -54 | - | initiating methionine |
Trp -53 | - | expression tag |
Ser -52 | - | expression tag |
His -51 | - | expression tag |
Pro -50 | - | expression tag |
Gln -49 | - | expression tag |
Phe -48 | - | expression tag |
Glu -47 | - | expression tag |
Lys -46 | - | expression tag |
Gly -45 | - | expression tag |
Gly -44 | - | expression tag |
Gly -43 | - | expression tag |
Ser -42 | - | expression tag |
Gly -41 | - | expression tag |
Gly -40 | - | expression tag |
Gly -39 | - | expression tag |
Ser -38 | - | expression tag |
Gly -37 | - | expression tag |
Gly -36 | - | expression tag |
Ser -35 | - | expression tag |
Ala -34 | - | expression tag |
Trp -33 | - | expression tag |
Ser -32 | - | expression tag |
His -31 | - | expression tag |
Pro -30 | - | expression tag |
Gln -29 | - | expression tag |
Phe -28 | - | expression tag |
Glu -27 | - | expression tag |
Lys -26 | - | expression tag |
Gly -25 | - | expression tag |
Gly -24 | - | expression tag |
Ser -23 | - | expression tag |
Gly -22 | - | expression tag |
Gly -21 | - | expression tag |
Asp -20 | - | expression tag |
Tyr -19 | - | expression tag |
Lys -18 | - | expression tag |
Asp -17 | - | expression tag |
Asp -16 | - | expression tag |
Asp -15 | - | expression tag |
Asp -14 | - | expression tag |
Lys -13 | - | expression tag |
Gly -12 | - | expression tag |
Gly -11 | - | expression tag |
Ser -10 | - | expression tag |
Gly -9 | - | expression tag |
Gly -8 | - | expression tag |
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Lys 0 | - | expression tag |
Ser 270 | Phe 270 | conflict |
Leu 274 | Val 274 | conflict |
Ile 275 | Leu 275 | conflict |
Leu 279 | Ile 279 | conflict |
Phe 280 | Tyr 280 | conflict |
Asn 283 | Val 283 | conflict |
Lys 285 | Thr 285 | conflict |
His 286 | Gln 286 | conflict |
A: 1286 - 1553 (UniProt: D0E0C2)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 184481.9 | |
Branched | Number of molecules | 1 |
Total formula weight | 748.7 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 5372.9 | |
All* | Total formula weight | 190603.5 |