8ETM
Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor
Summary for 8ETM
Entry DOI | 10.2210/pdb8etm/pdb |
EMDB information | 28594 |
Descriptor | Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid (2 entities in total) |
Functional Keywords | triglyceride biosynthesis, lipid storage, lipid metabolism, membrane protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 111781.38 |
Authors | Sui, X.,Kun, W.,Walther, T.,Farese, R.,Liao, M. (deposition date: 2022-10-17, release date: 2023-06-07, Last modification date: 2024-06-19) |
Primary citation | Sui, X.,Wang, K.,Song, K.,Xu, C.,Song, J.,Lee, C.W.,Liao, M.,Farese Jr., R.V.,Walther, T.C. Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14:3100-3100, 2023 Cited by PubMed: 37248213DOI: 10.1038/s41467-023-38934-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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