8E7C

Crystal Structure of Porcine Deltacoronavirus (HKU-15) Mpro with Pfizer Intravenous Inhibitor PF-00835231

Summary for 8E7C

Entry DOI	10.2210/pdb8e7c/pdb
Descriptor	Main Protease, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, GLYCEROL, ... (5 entities in total)
Functional Keywords	coronavirus, dcov, hku-15, deltacoronavirus, protease, drug resistance, complex, hydrolase, durg discovery, main protease, mpro, substrate complex, pfizer iv compound, pf-00835231, viral protein, viral protein-hydrolase-inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Porcine deltacoronavirus
Total number of polymer chains	2
Total formula weight	71857.96
Authors	Shaqra, A.M.,Schiffer, C.A. (deposition date: 2022-08-23, release date: 2023-03-29, Last modification date: 2023-10-25)
Primary citation	Zvornicanin, S.N.,Shaqra, A.M.,Huang, Q.J.,Ornelas, E.,Moghe, M.,Knapp, M.,Moquin, S.,Dovala, D.,Schiffer, C.A.,Kurt Yilmaz, N. Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses. Viruses, 15:-, 2023 Cited by PubMed: 36992489 DOI: 10.3390/v15030781 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation