8E7C

Crystal Structure of Porcine Deltacoronavirus (HKU-15) Mpro with Pfizer Intravenous Inhibitor PF-00835231

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Main Protease	polymer	307	34582.4	2	UniProt (A0A0E3N825) Pfam (PF05409)	Porcine deltacoronavirus
2	C, N (A, B)	N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide	non-polymer		474.6	2	Chemie (V2M)
3	D, E, F, G, O... (A, B)	GLYCEROL	non-polymer		92.1	13	Chemie (GOL)
4	H, I, J, K, L... (A, B)	DIMETHYL SULFOXIDE	non-polymer		78.1	7	Chemie (DMS)
5	Y, Z (A, B)	water	water		18.0	243	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69164.7
Non-Polymers*	Number of molecules	22
	Total formula weight	2693.3
All*	Total formula weight	71858.0

*Water molecules are not included.