8DFG

Crystal structure of potently neutralizing human monoclonal antibody 42D6 Fab in complex with MSP1-19

8DFG の概要

• エントリーDOI: 10.2210/pdb8dfg/pdb
• 分子名称: 42D6 Fab Heavy Chain, 42D6 Fab Light Chain, Merozoite surface protein 1, ... (4 entities in total)
• 機能のキーワード: merozoite surface protein 1 (msp1), antigen-antibody complex, plasmodium falciparum, antigenic diversion, structural protein-immune system complex, structural protein/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 123323.28

構造登録者

Patel, P.N.,Tang, W.K.,Tolia, N.H. (登録日: 2022-06-22, 公開日: 2022-10-12, 最終更新日: 2023-10-18)

• 主引用文献: Patel, P.N.,Dickey, T.H.,Hopp, C.S.,Diouf, A.,Tang, W.K.,Long, C.A.,Miura, K.,Crompton, P.D.,Tolia, N.H.; Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion.; Nat Commun, 13:5888-5888, 2022; PubMed: 36202833; DOI: 10.1038/s41467-022-33336-3

実験手法

X-RAY DIFFRACTION (2 Å)