8DCS

Cryo-EM structure of cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein

8DCS の概要

• エントリーDOI: 10.2210/pdb8dcs/pdb
• EMDBエントリー: 27329
• 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Nanobody 35, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
• 機能のキーワード: beta1-adrenergic receptor, cyanopindolol, partial agonist, signaling protein
• 由来する生物種: Bos taurus (cattle); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 163354.28

構造登録者

Su, M.,Paknejad, N.,Hite, R.K.,Huang, X.Y. (登録日: 2022-06-17, 公開日: 2022-07-27)

• 主引用文献: Su, M.,Paknejad, N.,Zhu, L.,Wang, J.,Do, H.N.,Miao, Y.,Liu, W.,Hite, R.K.,Huang, X.Y.; Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies.; Nat Commun, 13:4095-4095, 2022; PubMed: 35835792; DOI: 10.1038/s41467-022-31823-1

実験手法

ELECTRON MICROSCOPY (2.5 Å)