8DAF

Human SF-1 LBD bound to synthetic agonist 6N-10CA and bacterial phospholipid

Summary for 8DAF

Entry DOI	10.2210/pdb8daf/pdb
Descriptor	Steroidogenic factor 1, Nuclear receptor coactivator 2, 10-[(3aR,6S,6aR)-3-phenyl-3a-(1-phenylethenyl)-6-(sulfamoylamino)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid (non-preferred name), ... (5 entities in total)
Functional Keywords	sf-1, nuclear receptor, ligand, synthetic agonist, nuclear protein, steroidogenic factor-1, nr5a1
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	62140.51
Authors	D'Agostino, E.H.,Cato, M.L.,Ortlund, E.A. (deposition date: 2022-06-13, release date: 2023-06-28, Last modification date: 2023-10-25)
Primary citation	Cato, M.L.,D'Agostino, E.H.,Spurlin, R.M.,Flynn, A.R.,Cornelison, J.L.,Johnson, A.M.,Fujita, R.A.,Abraham, S.M.,Jui, N.T.,Ortlund, E.A. Comparison of activity, structure, and dynamics of SF-1 and LRH-1 complexed with small molecule modulators. J.Biol.Chem., 299:104921-104921, 2023 Cited by PubMed: 37328104 DOI: 10.1016/j.jbc.2023.104921 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.59 Å)

Structure validation