8D42

Human mitochondrial DNA polymerase gamma ternary complex with GT basepair in editing conformer (composite)

Summary for 8D42

• Entry DOI: 10.2210/pdb8d42/pdb
• EMDB information: 27154 27155 27163 27169 27170 27171 27172
• Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, DNA (5'-D(P*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*TP*AP*T)-3'), ... (6 entities in total)
• Functional Keywords: dna-binding protein, dna polymerase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 266004.21

Authors

Park, J.,Yin, Y.W. (deposition date: 2022-06-01, release date: 2023-05-24, Last modification date: 2023-07-05)

• Primary citation: Park, J.,Herrmann, G.K.,Mitchell, P.G.,Sherman, M.B.,Yin, Y.W.; Pol gamma coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity.; Nat.Struct.Mol.Biol., 30:812-823, 2023; PubMed: 37202477; DOI: 10.1038/s41594-023-00980-2

Experimental method

ELECTRON MICROSCOPY (2.91 Å)