8CTH
Cryo-EM structure of human METTL1-WDR4-tRNA(Phe) complex
Summary for 8CTH
Entry DOI | 10.2210/pdb8cth/pdb |
EMDB information | 26990 |
Descriptor | tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, Phe-tRNA, ... (4 entities in total) |
Functional Keywords | epitranscriptome, m7g, mettl1, methyltransferase, methylation, transferase, transferase-rna complex, transferase/rna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 103914.79 |
Authors | Li, J.,Wang, L.,Fontana, P.,Hunkeler, M.,Roy-Burman, S.S.,Wu, H.,Fishcer, E.S.,Gregory, R.I. (deposition date: 2022-05-14, release date: 2022-12-07, Last modification date: 2023-01-25) |
Primary citation | Li, J.,Wang, L.,Hahn, Q.,Nowak, R.P.,Viennet, T.,Orellana, E.A.,Roy Burman, S.S.,Yue, H.,Hunkeler, M.,Fontana, P.,Wu, H.,Arthanari, H.,Fischer, E.S.,Gregory, R.I. Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature, 613:391-397, 2023 Cited by PubMed: 36599985DOI: 10.1038/s41586-022-05566-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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