8CTH
Cryo-EM structure of human METTL1-WDR4-tRNA(Phe) complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006400 | biological_process | tRNA modification |
| A | 0008033 | biological_process | tRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008176 | molecular_function | tRNA (guanine(46)-N7)-methyltransferase activity |
| A | 0008298 | biological_process | intracellular mRNA localization |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030488 | biological_process | tRNA methylation |
| A | 0032259 | biological_process | methylation |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0034063 | biological_process | stress granule assembly |
| A | 0036265 | biological_process | RNA (guanine-N7)-methylation |
| A | 0036416 | biological_process | tRNA stabilization |
| A | 0043527 | cellular_component | tRNA methyltransferase complex |
| A | 0051028 | biological_process | mRNA transport |
| A | 0106004 | biological_process | tRNA (guanine-N7)-methylation |
| A | 0106143 | cellular_component | tRNA (m7G46) methyltransferase complex |
| A | 0160090 | molecular_function | internal mRNA (guanine-N7-)-methyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005694 | cellular_component | chromosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006400 | biological_process | tRNA modification |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008033 | biological_process | tRNA processing |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0036265 | biological_process | RNA (guanine-N7)-methylation |
| B | 0036416 | biological_process | tRNA stabilization |
| B | 0043527 | cellular_component | tRNA methyltransferase complex |
| B | 0106004 | biological_process | tRNA (guanine-N7)-methylation |
| B | 0106143 | cellular_component | tRNA (m7G46) methyltransferase complex |
| B | 0141106 | molecular_function | tRNA methyltransferase activator activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"AlphaC helix","evidences":[{"source":"PubMed","id":"36599985","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Alpha6 helix","evidences":[{"source":"PubMed","id":"36599985","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"36599982","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36599985","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36599982","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of human methyltransferase-like protein 1.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3CKK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D9L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36599985","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CTH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of human methyltransferase-like protein 1.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3CKK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKB/AKT1 and RPS6KA3","evidences":[{"source":"PubMed","id":"15861136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36599985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
