8CTH
Cryo-EM structure of human METTL1-WDR4-tRNA(Phe) complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | tRNA (guanine-N(7)-)-methyltransferase | polymer | 276 | 31516.0 | 1 | UniProt (Q9UBP6) Pfam (PF02390) In PDB | Homo sapiens (human) | Methyltransferase-like protein 1,mRNA (guanine-N(7)-)-methyltransferase,miRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine(46)-N(7))-methyltransferase,tRNA(m7G46)-methyltransferase |
2 | B | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 | polymer | 428 | 47363.5 | 1 | UniProt (P57081) Pfam (PF00400) In PDB | Homo sapiens (human) | Protein Wuho homolog,hWH,WD repeat-containing protein 4 |
3 | C | Phe-tRNA | polymer | 76 | 24650.9 | 1 | Saccharomyces cerevisiae (Yeast) | ||
4 | A | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) |
Sequence modifications
B: 1 - 412 (UniProt: P57081)
PDB | External Database | Details |
---|---|---|
Met -15 | - | initiating methionine |
Gly -14 | - | expression tag |
Ser -13 | - | expression tag |
Ser -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
Ser -5 | - | expression tag |
Gln -4 | - | expression tag |
Asp -3 | - | expression tag |
Pro -2 | - | expression tag |
Asn -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 103530.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 384.4 | |
All* | Total formula weight | 103914.8 |