8BW5

X-ray structure of the complex between human alpha thrombin and the duplex/quadruplex aptamer M08s-1_41mer

Summary for 8BW5

• Entry DOI: 10.2210/pdb8bw5/pdb
• Descriptor: Thrombin light chain, Thrombin heavy chain, M08s-1_41mer, ... (7 entities in total)
• Functional Keywords: dna aptamer, g-quadruplex, duplex, duplex/quadruplex, thrombin binding aptamer, thrombin, coagulation factor, anticoagulant, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 48932.44

Authors

Troisi, R.,Napolitano, V.,Sica, F. (deposition date: 2022-12-06, release date: 2023-07-19, Last modification date: 2023-09-20)

• Primary citation: Troisi, R.,Napolitano, V.,Rossitto, E.,Osman, W.,Nagano, M.,Wakui, K.,Popowicz, G.M.,Yoshimoto, K.,Sica, F.; Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide.; Nucleic Acids Res., 51:8880-8890, 2023; PubMed: 37503836; DOI: 10.1093/nar/gkad634

Experimental method

X-RAY DIFFRACTION (2.8 Å)