8BW5
X-ray structure of the complex between human alpha thrombin and the duplex/quadruplex aptamer M08s-1_41mer
Summary for 8BW5
Entry DOI | 10.2210/pdb8bw5/pdb |
Descriptor | Thrombin light chain, Thrombin heavy chain, M08s-1_41mer, ... (7 entities in total) |
Functional Keywords | dna aptamer, g-quadruplex, duplex, duplex/quadruplex, thrombin binding aptamer, thrombin, coagulation factor, anticoagulant, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 48932.44 |
Authors | Troisi, R.,Napolitano, V.,Sica, F. (deposition date: 2022-12-06, release date: 2023-07-19, Last modification date: 2023-09-20) |
Primary citation | Troisi, R.,Napolitano, V.,Rossitto, E.,Osman, W.,Nagano, M.,Wakui, K.,Popowicz, G.M.,Yoshimoto, K.,Sica, F. Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide. Nucleic Acids Res., 51:8880-8890, 2023 Cited by PubMed: 37503836DOI: 10.1093/nar/gkad634 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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