8BDS

Ternary complex between VCB, BRD4-BD1 and PROTAC 48

Summary for 8BDS

Entry DOI	10.2210/pdb8bds/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (8 entities in total)
Functional Keywords	protac, degrader, complex, e3 ligase, vhl, vcb, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	58318.41
Authors	Sorrell, F.J.,Mueller, J.E.,Lehmann, M.,Wegener, A. (deposition date: 2022-10-20, release date: 2023-02-15, Last modification date: 2024-02-07)
Primary citation	Krieger, J.,Sorrell, F.J.,Wegener, A.A.,Leuthner, B.,Machrouhi-Porcher, F.,Hecht, M.,Leibrock, E.M.,Muller, J.E.,Eisert, J.,Hartung, I.V.,Schlesiger, S. Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. Chemmedchem, 18:e202200615-e202200615, 2023 Cited by PubMed: 36749883 DOI: 10.1002/cmdc.202200615 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation