8A0F
Crystal structure of human deoxyhypusine synthase variant K329A in complex with NAD and SPD
Summary for 8A0F
Entry DOI | 10.2210/pdb8a0f/pdb |
Related | 6XXJ 7A6S 7A6T 8A0E |
Descriptor | Deoxyhypusine synthase, SPERMIDINE, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | hypusination, transferase, posttranslational modification |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 84122.77 |
Authors | Wator, E.,Wilk, P.,Grudnik, P. (deposition date: 2022-05-27, release date: 2023-04-05, Last modification date: 2024-02-07) |
Primary citation | Wator, E.,Wilk, P.,Biela, A.,Rawski, M.,Zak, K.M.,Steinchen, W.,Bange, G.,Glatt, S.,Grudnik, P. Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14:1698-1698, 2023 Cited by PubMed: 36973244DOI: 10.1038/s41467-023-37305-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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