8W6P
Crystal structure of dimeric murine SMPDL3A
Summary for 8W6P
Entry DOI | 10.2210/pdb8w6p/pdb |
Descriptor | Acid sphingomyelinase-like phosphodiesterase 3a, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | innate immunity, lipid metabolism, hydrolase |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 2 |
Total formula weight | 97210.11 |
Authors | |
Primary citation | Hou, Y.,Wang, Z.,Liu, P.,Wei, X.,Zhang, Z.,Fan, S.,Zhang, L.,Han, F.,Song, Y.,Chu, L.,Zhang, C. SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56:2492-2507.e10, 2023 Cited by PubMed: 37890481DOI: 10.1016/j.immuni.2023.10.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
Download full validation report