8TZX

Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1

Summary for 8TZX

• Entry DOI: 10.2210/pdb8tzx/pdb
• Descriptor: Protein cereblon, DNA damage-binding protein 1, Protein Wiz, ... (8 entities in total)
• Functional Keywords: complex, glue, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 280743.67

Authors

Clifton, M.C.,Ma, X.,Ornelas, E. (deposition date: 2023-08-28, release date: 2024-07-10, Last modification date: 2024-07-17)

• Primary citation: Ting, P.Y.,Borikar, S.,Kerrigan, J.R.,Thomsen, N.M.,Aghania, E.,Hinman, A.E.,Reyes, A.,Pizzato, N.,Fodor, B.D.,Wu, F.,Belew, M.S.,Mao, X.,Wang, J.,Chitnis, S.,Niu, W.,Hachey, A.,Cobb, J.S.,Savage, N.A.,Burke, A.,Paulk, J.,Dovala, D.,Lin, J.,Clifton, M.C.,Ornelas, E.,Ma, X.,Ware, N.F.,Sanchez, C.C.,Taraszka, J.,Terranova, R.,Knehr, J.,Altorfer, M.,Barnes, S.W.,Beckwith, R.E.J.,Solomon, J.M.,Dales, N.A.,Patterson, A.W.,Wagner, J.,Bouwmeester, T.,Dranoff, G.,Stevenson, S.C.,Bradner, J.E.; A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.; Science, 385:91-99, 2024; PubMed: 38963839; DOI: 10.1126/science.adk6129

Experimental method

X-RAY DIFFRACTION (3.15 Å)