8TBQ
The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody
Summary for 8TBQ
Entry DOI | 10.2210/pdb8tbq/pdb |
Descriptor | SNS-101 Fab heavy chain, SNS-101 Fab light chain, V-type immunoglobulin domain-containing suppressor of T-cell activation, ... (6 entities in total) |
Functional Keywords | vista, ph-selective, sns-101, pd-1, protein binding, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 132211.84 |
Authors | van der Horst, E.H.,Mukherjee, A.,Thisted, T. (deposition date: 2023-06-29, release date: 2024-03-20) |
Primary citation | Thisted, T.,Smith, F.D.,Zhang, G.,Feng, F.,Kleschenko, Y.,Mukherjee, A.,Jiang, Z.,Malhotra, K.,Biesova, Z.,Onumajuru, A.,Gaelle, M.,Takeuchi, Y.,Thiam, K.,Schreiber, R.D.,van der Horst, E.H. The pH-selective anti-VISTA antibody SNS-101 displays a favorable pharmacokinetic and safety profile and promotes anti-tumoral M1 macrophage polarization in PD-1 refractory settings To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.593 Å) |
Structure validation
Download full validation report