8SSZ

The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

Summary for 8SSZ

Entry DOI	10.2210/pdb8ssz/pdb
EMDB information	40752 40753 40754 40755 40756 40757
Descriptor	Neuronal acetylcholine receptor subunit alpha-4, N-OCTANE, Neuronal acetylcholine receptor subunit beta-2, ... (11 entities in total)
Functional Keywords	cys-loop ligand-gated pentameric ion channels, cation-selective channel, acetylcholine, calcium, transport protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	11
Total formula weight	538579.28
Authors	Kang, G.,Hibbs, R.E. (deposition date: 2023-05-09, release date: 2024-02-07, Last modification date: 2024-08-21)
Primary citation	Mazzaferro, S.,Kang, G.,Natarajan, K.,Hibbs, R.E.,Sine, S.M. Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor. Br.J.Pharmacol., 181:1973-1992, 2024 Cited by PubMed: 38454578 DOI: 10.1111/bph.16321 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.64 Å)

Structure validation