Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8SSZ

The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001508	biological_process	action potential
A	0001666	biological_process	response to hypoxia
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0005892	cellular_component	acetylcholine-gated channel complex
A	0006281	biological_process	DNA repair
A	0006338	biological_process	chromatin remodeling
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006979	biological_process	response to oxidative stress
A	0007165	biological_process	signal transduction
A	0007268	biological_process	chemical synaptic transmission
A	0007271	biological_process	synaptic transmission, cholinergic
A	0007274	biological_process	neuromuscular synaptic transmission
A	0009897	cellular_component	external side of plasma membrane
A	0014059	biological_process	regulation of dopamine secretion
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0015464	molecular_function	acetylcholine receptor activity
A	0016020	cellular_component	membrane
A	0019233	biological_process	sensory perception of pain
A	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
A	0030425	cellular_component	dendrite
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034703	cellular_component	cation channel complex
A	0035094	biological_process	response to nicotine
A	0035095	biological_process	behavioral response to nicotine
A	0042113	biological_process	B cell activation
A	0042166	molecular_function	acetylcholine binding
A	0042391	biological_process	regulation of membrane potential
A	0042734	cellular_component	presynaptic membrane
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0045202	cellular_component	synapse
A	0045211	cellular_component	postsynaptic membrane
A	0050877	biological_process	nervous system process
A	0050890	biological_process	cognition
A	0051899	biological_process	membrane depolarization
A	0060079	biological_process	excitatory postsynaptic potential
A	0060080	biological_process	inhibitory postsynaptic potential
A	0095500	biological_process	acetylcholine receptor signaling pathway
A	0097060	cellular_component	synaptic membrane
A	0098878	cellular_component	neurotransmitter receptor complex
A	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
A	0140658	molecular_function	ATP-dependent chromatin remodeler activity
B	0001666	biological_process	response to hypoxia
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0005892	cellular_component	acetylcholine-gated channel complex
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0006939	biological_process	smooth muscle contraction
B	0007165	biological_process	signal transduction
B	0007268	biological_process	chemical synaptic transmission
B	0007271	biological_process	synaptic transmission, cholinergic
B	0007601	biological_process	visual perception
B	0007605	biological_process	sensory perception of sound
B	0007612	biological_process	learning
B	0007613	biological_process	memory
B	0007626	biological_process	locomotory behavior
B	0008306	biological_process	associative learning
B	0008542	biological_process	visual learning
B	0009897	cellular_component	external side of plasma membrane
B	0014059	biological_process	regulation of dopamine secretion
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0015464	molecular_function	acetylcholine receptor activity
B	0016020	cellular_component	membrane
B	0019233	biological_process	sensory perception of pain
B	0021562	biological_process	vestibulocochlear nerve development
B	0021631	biological_process	optic nerve morphogenesis
B	0021771	biological_process	lateral geniculate nucleus development
B	0021952	biological_process	central nervous system projection neuron axonogenesis
B	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
B	0030890	biological_process	positive regulation of B cell proliferation
B	0032225	biological_process	regulation of synaptic transmission, dopaminergic
B	0033603	biological_process	positive regulation of dopamine secretion
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035094	biological_process	response to nicotine
B	0035095	biological_process	behavioral response to nicotine
B	0035176	biological_process	social behavior
B	0042053	biological_process	regulation of dopamine metabolic process
B	0042113	biological_process	B cell activation
B	0042166	molecular_function	acetylcholine binding
B	0042220	biological_process	response to cocaine
B	0042320	biological_process	regulation of circadian sleep/wake cycle, REM sleep
B	0042734	cellular_component	presynaptic membrane
B	0043005	cellular_component	neuron projection
B	0044853	cellular_component	plasma membrane raft
B	0045202	cellular_component	synapse
B	0045211	cellular_component	postsynaptic membrane
B	0045471	biological_process	response to ethanol
B	0045759	biological_process	negative regulation of action potential
B	0048814	biological_process	regulation of dendrite morphogenesis
B	0050877	biological_process	nervous system process
B	0050890	biological_process	cognition
B	0051899	biological_process	membrane depolarization
B	0051963	biological_process	regulation of synapse assembly
B	0060078	biological_process	regulation of postsynaptic membrane potential
B	0060079	biological_process	excitatory postsynaptic potential
B	0060084	biological_process	synaptic transmission involved in micturition
B	0095500	biological_process	acetylcholine receptor signaling pathway
B	0097060	cellular_component	synaptic membrane
B	0098878	cellular_component	neurotransmitter receptor complex
B	1905144	biological_process	response to acetylcholine
C	0001666	biological_process	response to hypoxia
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0005892	cellular_component	acetylcholine-gated channel complex
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006939	biological_process	smooth muscle contraction
C	0007165	biological_process	signal transduction
C	0007268	biological_process	chemical synaptic transmission
C	0007271	biological_process	synaptic transmission, cholinergic
C	0007601	biological_process	visual perception
C	0007605	biological_process	sensory perception of sound
C	0007612	biological_process	learning
C	0007613	biological_process	memory
C	0007626	biological_process	locomotory behavior
C	0008306	biological_process	associative learning
C	0008542	biological_process	visual learning
C	0009897	cellular_component	external side of plasma membrane
C	0014059	biological_process	regulation of dopamine secretion
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0015464	molecular_function	acetylcholine receptor activity
C	0016020	cellular_component	membrane
C	0019233	biological_process	sensory perception of pain
C	0021562	biological_process	vestibulocochlear nerve development
C	0021631	biological_process	optic nerve morphogenesis
C	0021771	biological_process	lateral geniculate nucleus development
C	0021952	biological_process	central nervous system projection neuron axonogenesis
C	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
C	0030890	biological_process	positive regulation of B cell proliferation
C	0032225	biological_process	regulation of synaptic transmission, dopaminergic
C	0033603	biological_process	positive regulation of dopamine secretion
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035094	biological_process	response to nicotine
C	0035095	biological_process	behavioral response to nicotine
C	0035176	biological_process	social behavior
C	0042053	biological_process	regulation of dopamine metabolic process
C	0042113	biological_process	B cell activation
C	0042166	molecular_function	acetylcholine binding
C	0042220	biological_process	response to cocaine
C	0042320	biological_process	regulation of circadian sleep/wake cycle, REM sleep
C	0042734	cellular_component	presynaptic membrane
C	0043005	cellular_component	neuron projection
C	0044853	cellular_component	plasma membrane raft
C	0045202	cellular_component	synapse
C	0045211	cellular_component	postsynaptic membrane
C	0045471	biological_process	response to ethanol
C	0045759	biological_process	negative regulation of action potential
C	0048814	biological_process	regulation of dendrite morphogenesis
C	0050877	biological_process	nervous system process
C	0050890	biological_process	cognition
C	0051899	biological_process	membrane depolarization
C	0051963	biological_process	regulation of synapse assembly
C	0060078	biological_process	regulation of postsynaptic membrane potential
C	0060079	biological_process	excitatory postsynaptic potential
C	0060084	biological_process	synaptic transmission involved in micturition
C	0095500	biological_process	acetylcholine receptor signaling pathway
C	0097060	cellular_component	synaptic membrane
C	0098878	cellular_component	neurotransmitter receptor complex
C	1905144	biological_process	response to acetylcholine
D	0001508	biological_process	action potential
D	0001666	biological_process	response to hypoxia
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0005892	cellular_component	acetylcholine-gated channel complex
D	0006281	biological_process	DNA repair
D	0006338	biological_process	chromatin remodeling
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0006979	biological_process	response to oxidative stress
D	0007165	biological_process	signal transduction
D	0007268	biological_process	chemical synaptic transmission
D	0007271	biological_process	synaptic transmission, cholinergic
D	0007274	biological_process	neuromuscular synaptic transmission
D	0009897	cellular_component	external side of plasma membrane
D	0014059	biological_process	regulation of dopamine secretion
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0015464	molecular_function	acetylcholine receptor activity
D	0016020	cellular_component	membrane
D	0019233	biological_process	sensory perception of pain
D	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
D	0030425	cellular_component	dendrite
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034703	cellular_component	cation channel complex
D	0035094	biological_process	response to nicotine
D	0035095	biological_process	behavioral response to nicotine
D	0042113	biological_process	B cell activation
D	0042166	molecular_function	acetylcholine binding
D	0042391	biological_process	regulation of membrane potential
D	0042734	cellular_component	presynaptic membrane
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0045202	cellular_component	synapse
D	0045211	cellular_component	postsynaptic membrane
D	0050877	biological_process	nervous system process
D	0050890	biological_process	cognition
D	0051899	biological_process	membrane depolarization
D	0060079	biological_process	excitatory postsynaptic potential
D	0060080	biological_process	inhibitory postsynaptic potential
D	0095500	biological_process	acetylcholine receptor signaling pathway
D	0097060	cellular_component	synaptic membrane
D	0098878	cellular_component	neurotransmitter receptor complex
D	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
D	0140658	molecular_function	ATP-dependent chromatin remodeler activity
E	0001666	biological_process	response to hypoxia
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0005892	cellular_component	acetylcholine-gated channel complex
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0006939	biological_process	smooth muscle contraction
E	0007165	biological_process	signal transduction
E	0007268	biological_process	chemical synaptic transmission
E	0007271	biological_process	synaptic transmission, cholinergic
E	0007601	biological_process	visual perception
E	0007605	biological_process	sensory perception of sound
E	0007612	biological_process	learning
E	0007613	biological_process	memory
E	0007626	biological_process	locomotory behavior
E	0008306	biological_process	associative learning
E	0008542	biological_process	visual learning
E	0009897	cellular_component	external side of plasma membrane
E	0014059	biological_process	regulation of dopamine secretion
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0015464	molecular_function	acetylcholine receptor activity
E	0016020	cellular_component	membrane
E	0019233	biological_process	sensory perception of pain
E	0021562	biological_process	vestibulocochlear nerve development
E	0021631	biological_process	optic nerve morphogenesis
E	0021771	biological_process	lateral geniculate nucleus development
E	0021952	biological_process	central nervous system projection neuron axonogenesis
E	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
E	0030890	biological_process	positive regulation of B cell proliferation
E	0032225	biological_process	regulation of synaptic transmission, dopaminergic
E	0033603	biological_process	positive regulation of dopamine secretion
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035094	biological_process	response to nicotine
E	0035095	biological_process	behavioral response to nicotine
E	0035176	biological_process	social behavior
E	0042053	biological_process	regulation of dopamine metabolic process
E	0042113	biological_process	B cell activation
E	0042166	molecular_function	acetylcholine binding
E	0042220	biological_process	response to cocaine
E	0042320	biological_process	regulation of circadian sleep/wake cycle, REM sleep
E	0042734	cellular_component	presynaptic membrane
E	0043005	cellular_component	neuron projection
E	0044853	cellular_component	plasma membrane raft
E	0045202	cellular_component	synapse
E	0045211	cellular_component	postsynaptic membrane
E	0045471	biological_process	response to ethanol
E	0045759	biological_process	negative regulation of action potential
E	0048814	biological_process	regulation of dendrite morphogenesis
E	0050877	biological_process	nervous system process
E	0050890	biological_process	cognition
E	0051899	biological_process	membrane depolarization
E	0051963	biological_process	regulation of synapse assembly
E	0060078	biological_process	regulation of postsynaptic membrane potential
E	0060079	biological_process	excitatory postsynaptic potential
E	0060084	biological_process	synaptic transmission involved in micturition
E	0095500	biological_process	acetylcholine receptor signaling pathway
E	0097060	cellular_component	synaptic membrane
E	0098878	cellular_component	neurotransmitter receptor complex
E	1905144	biological_process	response to acetylcholine

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CkIeVkhFPfDqqnC

Chain	Residue	Details
B	CYS130-CYS144
A	CYS135-CYS149

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
F	TYR197-HIS203

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	301
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29720657","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CNJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38454578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ST0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ST1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ST3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38454578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ST0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ST3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P04757","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27698419","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KXI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	675
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29720657","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CNJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	12
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29720657","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CNJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Site: {"description":"Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site","evidences":[{"source":"UniProtKB","id":"P12390","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	6
Details	Site: {"description":"Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA","evidences":[{"source":"UniProtKB","id":"P12390","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)