8SIA

Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor NS8593 in closed state

Summary for 8SIA

• Entry DOI: 10.2210/pdb8sia/pdb
• Related: 8SI2 8SI3 8SI4 8SI5 8SI6 8SI7 8SI8
• EMDB information: 40496 40497 40498 40499 40500 40501 40502 40504
• Descriptor: Transient receptor potential cation channel subfamily M member 7, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... (6 entities in total)
• Functional Keywords: transient receptor potential m family member 7, trp, channel, trpm7, trp channels, membrane protein, magnesium channel, inhibitor, ligand, ns8593
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 631842.57

Authors

Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-04-14, release date: 2023-05-17, Last modification date: 2023-05-24)

• Primary citation: Nadezhdin, K.D.,Correia, L.,Narangoda, C.,Patel, D.S.,Neuberger, A.,Gudermann, T.,Kurnikova, M.G.,Chubanov, V.,Sobolevsky, A.I.; Structural mechanisms of TRPM7 activation and inhibition.; Nat Commun, 14:2639-2639, 2023; PubMed: 37156763; DOI: 10.1038/s41467-023-38362-3

Experimental method

ELECTRON MICROSCOPY (2.91 Å)