8SIA
Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor NS8593 in closed state
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0051262 | biological_process | protein tetramerization |
A | 0055085 | biological_process | transmembrane transport |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0051262 | biological_process | protein tetramerization |
B | 0055085 | biological_process | transmembrane transport |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0051262 | biological_process | protein tetramerization |
C | 0055085 | biological_process | transmembrane transport |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0051262 | biological_process | protein tetramerization |
D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 480 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | ASN756-TYR776 | |
B | LEU963-ASN983 | |
B | MET996-VAL1016 | |
B | PHE1075-PHE1095 | |
C | ASN756-TYR776 | |
C | PHE856-VAL876 | |
C | TRP919-PHE939 | |
C | LEU963-ASN983 | |
C | MET996-VAL1016 | |
C | PHE1075-PHE1095 | |
D | ASN756-TYR776 | |
A | PHE856-VAL876 | |
D | PHE856-VAL876 | |
D | TRP919-PHE939 | |
D | LEU963-ASN983 | |
D | MET996-VAL1016 | |
D | PHE1075-PHE1095 | |
A | TRP919-PHE939 | |
A | LEU963-ASN983 | |
A | MET996-VAL1016 | |
A | PHE1075-PHE1095 | |
B | ASN756-TYR776 | |
B | PHE856-VAL876 | |
B | TRP919-PHE939 |
site_id | SWS_FT_FI2 |
Number of Residues | 540 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
A | LYS777-LYS855 | |
C | GLY940-ARG962 | |
C | PRO1017-ASP1035 | |
C | ALA1057-PRO1074 | |
D | LYS777-LYS855 | |
D | GLY940-ARG962 | |
D | PRO1017-ASP1035 | |
D | ALA1057-PRO1074 | |
A | GLY940-ARG962 | |
A | PRO1017-ASP1035 | |
A | ALA1057-PRO1074 | |
B | LYS777-LYS855 | |
B | GLY940-ARG962 | |
B | PRO1017-ASP1035 | |
B | ALA1057-PRO1074 | |
C | LYS777-LYS855 |
site_id | SWS_FT_FI3 |
Number of Residues | 208 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | LYS877-VAL918 | |
A | GLN984-LYS995 | |
B | LYS877-VAL918 | |
B | GLN984-LYS995 | |
C | LYS877-VAL918 | |
C | GLN984-LYS995 | |
D | LYS877-VAL918 | |
D | GLN984-LYS995 |
site_id | SWS_FT_FI4 |
Number of Residues | 80 |
Details | INTRAMEM: Pore-forming => ECO:0000255 |
Chain | Residue | Details |
A | ILE1036-CYS1056 | |
B | ILE1036-CYS1056 | |
C | ILE1036-CYS1056 | |
D | ILE1036-CYS1056 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96QT4 |
Chain | Residue | Details |
A | SER101 | |
B | SER101 | |
C | SER101 | |
D | SER101 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:22222377 |
Chain | Residue | Details |
A | SER1224 | |
B | SER1224 | |
C | SER1224 | |
D | SER1224 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
Chain | Residue | Details |
A | SER1255 | |
B | SER1255 | |
C | SER1255 | |
D | SER1255 |