8SIA
Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor NS8593 in closed state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily M member 7 | polymer | 1279 | 146902.9 | 4 | UniProt (Q923J1) Pfam (PF18139) Pfam (PF00520) Pfam (PF16519) | Mus musculus (house mouse) | Channel-kinase 1,Long transient receptor potential channel 7,LTrpC-7,LTrpC7,Transient receptor potential-phospholipase C-interacting kinase,TRP-PLIK |
| 2 | AA, AB, BA, DA, DB... (B, C, A, D) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 52 | Chemie (POV) | |||
| 3 | BB, EB, P, S (C, A) | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol | non-polymer | 516.8 | 4 | Chemie (DU0) | |||
| 4 | CB, LA, Q, QB (C, B, A, D) | N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine | non-polymer | 263.3 | 4 | Chemie (6RA) | |||
| 5 | W (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | CA, IB, SA, X (B, D, C) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) |
Sequence modifications
A, B, C, D: 2 - 1280 (UniProt: Q923J1)
| PDB | External Database | Details |
|---|---|---|
| Gln 1098 | Asn 1098 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 587611.6 | |
| Non-Polymers* | Number of molecules | 65 |
| Total formula weight | 44231.0 | |
| All* | Total formula weight | 631842.6 |
