8QEZ
Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution
Summary for 8QEZ
Entry DOI | 10.2210/pdb8qez/pdb |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ... (9 entities in total) |
Functional Keywords | ampa receptor ligand-binding domain, glua2 s1s2j-l504y-n775s, bpam395, positive allosteric modulation, membrane protein |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 3 |
Total formula weight | 90682.77 |
Authors | Dorosz, J.,Laulumaa, S.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2023-09-01, release date: 2023-12-27) |
Primary citation | Francotte, P.,Bay, Y.,Goffin, E.,Colson, T.,Lesenfants, C.,Dorosz, J.,Laulumaa, S.,Fraikin, P.,de Tullio, P.,Beaufour, C.,Botez, I.,Pickering, D.S.,Frydenvang, K.,Danober, L.,Kristensen, A.S.,Kastrup, J.S.,Pirotte, B. Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. Eur.J.Med.Chem., 264:116036-116036, 2023 Cited by PubMed: 38101041DOI: 10.1016/j.ejmech.2023.116036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report