8PAU
Crystal structure of MAP4K1 with a SMOL inhibitor
Summary for 8PAU
Entry DOI | 10.2210/pdb8pau/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 1, [(5~{R})-2-[[3,5-bis(fluoranyl)-4-[[3-(trifluoromethyl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]amino]-5-fluoranyl-4,6-dihydro-1,3-oxazin-5-yl]methanol (3 entities in total) |
Functional Keywords | kinase, inhibitor, drug discovery, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65531.89 |
Authors | |
Primary citation | Mowat, J.,Offringa, R. Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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