8PAU

Crystal structure of MAP4K1 with a SMOL inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Mitogen-activated protein kinase kinase kinase kinase 1	polymer	288	32305.6	2	UniProt (Q92918) Pfam (PF00069) In PDB	Homo sapiens (human)	Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEK kinase kinase 1,MEKKK 1
2	A, B	[(5~{R})-2-[[3,5-bis(fluoranyl)-4-[[3-(trifluoromethyl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]amino]-5-fluoranyl-4,6-dihydro-1,3-oxazin-5-yl]methanol	non-polymer		460.3	2	Chemie (XOR)
3		water	water		18.0	17	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64611.2
Non-Polymers*	Number of molecules	2
	Total formula weight	920.7
All*	Total formula weight	65531.9

*Water molecules are not included.