8IZC

Human CK1 Delta Kinase structure bound to Inhibitor

Summary for 8IZC

• Entry DOI: 10.2210/pdb8izc/pdb
• Descriptor: Casein kinase I isoform delta, SULFATE ION, ~{N}5-~{tert}-butyl-2-(3-chloranyl-4-fluoranyl-phenyl)-6,7-dihydro-4~{H}-pyrazolo[1,5-a]pyrazine-3,5-dicarboxamide, ... (4 entities in total)
• Functional Keywords: ck1, kinase, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 68882.14

Authors

Ghosh, K. (deposition date: 2023-04-06, release date: 2024-04-10)

• Primary citation: Velaparthi, U.,Selvakumar, K.; The Discovery of BMS-986164, a Potent, Selective and Orally Efficacious CK1d/e/a Inhibitor from Pyrazolo-Piperazine Chemotype; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)