8HLB
Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
Summary for 8HLB
Entry DOI | 10.2210/pdb8hlb/pdb |
EMDB information | 34871 |
Descriptor | Tumor necrosis factor receptor superfamily member 1B,Maltose/maltodextrin-binding periplasmic protein, TR109 heavy chain, TR109 light chain, ... (5 entities in total) |
Functional Keywords | tnfr2, biparatopic antibody, antagonist, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 158513.69 |
Authors | Akiba, H.,Fujita, J.,Ise, T.,Nishiyama, K.,Miyata, T.,Kato, T.,Namba, K.,Ohno, H.,Kamada, H.,Nagata, S.,Tsumoto, K. (deposition date: 2022-11-29, release date: 2023-10-04) |
Primary citation | Akiba, H.,Fujita, J.,Ise, T.,Nishiyama, K.,Miyata, T.,Kato, T.,Namba, K.,Ohno, H.,Kamada, H.,Nagata, S.,Tsumoto, K. Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection. Commun Biol, 6:987-987, 2023 Cited by PubMed: 37758868DOI: 10.1038/s42003-023-05326-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.63 Å) |
Structure validation
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