8GF8
Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids
Summary for 8GF8
Entry DOI | 10.2210/pdb8gf8/pdb |
Related | 8GF9 8GFA |
EMDB information | 29981 29982 29983 |
Descriptor | Transient receptor potential cation channel subfamily V member 1, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, ... (4 entities in total) |
Functional Keywords | transient receptor potential v family member 1, vanilloid, trp, apo, human, channel, trpv1, trp channels, pain, membrane protein, cnw11, nanodiscs, thermo-trp, temperature sensation |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 529178.39 |
Authors | Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2023-03-07, release date: 2023-05-10) |
Primary citation | Neuberger, A.,Oda, M.,Nikolaev, Y.A.,Nadezhdin, K.D.,Gracheva, E.O.,Bagriantsev, S.N.,Sobolevsky, A.I. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14:2451-2451, 2023 Cited by PubMed: 37117175DOI: 10.1038/s41467-023-38162-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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