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8GF8

Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001659biological_processtemperature homeostasis
A0001660biological_processfever generation
A0001774biological_processmicroglial cell activation
A0002024biological_processdiet induced thermogenesis
A0002790biological_processpeptide secretion
A0003085biological_processnegative regulation of systemic arterial blood pressure
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006091biological_processgeneration of precursor metabolites and energy
A0006629biological_processlipid metabolic process
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007166biological_processcell surface receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007635biological_processchemosensory behavior
A0008218biological_processbioluminescence
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0009268biological_processresponse to pH
A0009408biological_processresponse to heat
A0009897cellular_componentexternal side of plasma membrane
A0010243biological_processresponse to organonitrogen compound
A0010459biological_processnegative regulation of heart rate
A0010917biological_processnegative regulation of mitochondrial membrane potential
A0014047biological_processglutamate secretion
A0014832biological_processurinary bladder smooth muscle contraction
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0017081molecular_functionchloride channel regulator activity
A0019233biological_processsensory perception of pain
A0019722biological_processcalcium-mediated signaling
A0030425cellular_componentdendrite
A0032591cellular_componentdendritic spine membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034605biological_processcellular response to heat
A0035091molecular_functionphosphatidylinositol binding
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043434biological_processresponse to peptide hormone
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0046872molecular_functionmetal ion binding
A0048265biological_processresponse to pain
A0048266biological_processbehavioral response to pain
A0050954biological_processsensory perception of mechanical stimulus
A0050955biological_processthermoception
A0050960biological_processdetection of temperature stimulus involved in thermoception
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
A0051219molecular_functionphosphoprotein binding
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0060079biological_processexcitatory postsynaptic potential
A0060083biological_processsmooth muscle contraction involved in micturition
A0070588biological_processcalcium ion transmembrane transport
A0071312biological_processcellular response to alkaloid
A0071318biological_processcellular response to ATP
A0071345biological_processcellular response to cytokine stimulus
A0071356biological_processcellular response to tumor necrosis factor
A0071363biological_processcellular response to growth factor stimulus
A0071468biological_processcellular response to acidic pH
A0071502biological_processcellular response to temperature stimulus
A0090212biological_processnegative regulation of establishment of blood-brain barrier
A0097603molecular_functiontemperature-gated ion channel activity
A0098703biological_processcalcium ion import across plasma membrane
A1901594biological_processresponse to capsazepine
A1990090biological_processcellular response to nerve growth factor stimulus
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001659biological_processtemperature homeostasis
B0001660biological_processfever generation
B0001774biological_processmicroglial cell activation
B0002024biological_processdiet induced thermogenesis
B0002790biological_processpeptide secretion
B0003085biological_processnegative regulation of systemic arterial blood pressure
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
B0005245molecular_functionvoltage-gated calcium channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006091biological_processgeneration of precursor metabolites and energy
B0006629biological_processlipid metabolic process
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007166biological_processcell surface receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007635biological_processchemosensory behavior
B0008218biological_processbioluminescence
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0009268biological_processresponse to pH
B0009408biological_processresponse to heat
B0009897cellular_componentexternal side of plasma membrane
B0010243biological_processresponse to organonitrogen compound
B0010459biological_processnegative regulation of heart rate
B0010917biological_processnegative regulation of mitochondrial membrane potential
B0014047biological_processglutamate secretion
B0014832biological_processurinary bladder smooth muscle contraction
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0017081molecular_functionchloride channel regulator activity
B0019233biological_processsensory perception of pain
B0019722biological_processcalcium-mediated signaling
B0030425cellular_componentdendrite
B0032591cellular_componentdendritic spine membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034605biological_processcellular response to heat
B0035091molecular_functionphosphatidylinositol binding
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043434biological_processresponse to peptide hormone
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0046872molecular_functionmetal ion binding
B0048265biological_processresponse to pain
B0048266biological_processbehavioral response to pain
B0050954biological_processsensory perception of mechanical stimulus
B0050955biological_processthermoception
B0050960biological_processdetection of temperature stimulus involved in thermoception
B0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
B0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
B0051219molecular_functionphosphoprotein binding
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0060079biological_processexcitatory postsynaptic potential
B0060083biological_processsmooth muscle contraction involved in micturition
B0070588biological_processcalcium ion transmembrane transport
B0071312biological_processcellular response to alkaloid
B0071318biological_processcellular response to ATP
B0071345biological_processcellular response to cytokine stimulus
B0071356biological_processcellular response to tumor necrosis factor
B0071363biological_processcellular response to growth factor stimulus
B0071468biological_processcellular response to acidic pH
B0071502biological_processcellular response to temperature stimulus
B0090212biological_processnegative regulation of establishment of blood-brain barrier
B0097603molecular_functiontemperature-gated ion channel activity
B0098703biological_processcalcium ion import across plasma membrane
B1901594biological_processresponse to capsazepine
B1990090biological_processcellular response to nerve growth factor stimulus
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001659biological_processtemperature homeostasis
C0001660biological_processfever generation
C0001774biological_processmicroglial cell activation
C0002024biological_processdiet induced thermogenesis
C0002790biological_processpeptide secretion
C0003085biological_processnegative regulation of systemic arterial blood pressure
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006091biological_processgeneration of precursor metabolites and energy
C0006629biological_processlipid metabolic process
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007166biological_processcell surface receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007635biological_processchemosensory behavior
C0008218biological_processbioluminescence
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0009268biological_processresponse to pH
C0009408biological_processresponse to heat
C0009897cellular_componentexternal side of plasma membrane
C0010243biological_processresponse to organonitrogen compound
C0010459biological_processnegative regulation of heart rate
C0010917biological_processnegative regulation of mitochondrial membrane potential
C0014047biological_processglutamate secretion
C0014832biological_processurinary bladder smooth muscle contraction
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0017081molecular_functionchloride channel regulator activity
C0019233biological_processsensory perception of pain
C0019722biological_processcalcium-mediated signaling
C0030425cellular_componentdendrite
C0032591cellular_componentdendritic spine membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034605biological_processcellular response to heat
C0035091molecular_functionphosphatidylinositol binding
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043434biological_processresponse to peptide hormone
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0046872molecular_functionmetal ion binding
C0048265biological_processresponse to pain
C0048266biological_processbehavioral response to pain
C0050954biological_processsensory perception of mechanical stimulus
C0050955biological_processthermoception
C0050960biological_processdetection of temperature stimulus involved in thermoception
C0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
C0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
C0051219molecular_functionphosphoprotein binding
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0060079biological_processexcitatory postsynaptic potential
C0060083biological_processsmooth muscle contraction involved in micturition
C0070588biological_processcalcium ion transmembrane transport
C0071312biological_processcellular response to alkaloid
C0071318biological_processcellular response to ATP
C0071345biological_processcellular response to cytokine stimulus
C0071356biological_processcellular response to tumor necrosis factor
C0071363biological_processcellular response to growth factor stimulus
C0071468biological_processcellular response to acidic pH
C0071502biological_processcellular response to temperature stimulus
C0090212biological_processnegative regulation of establishment of blood-brain barrier
C0097603molecular_functiontemperature-gated ion channel activity
C0098703biological_processcalcium ion import across plasma membrane
C1901594biological_processresponse to capsazepine
C1990090biological_processcellular response to nerve growth factor stimulus
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001659biological_processtemperature homeostasis
D0001660biological_processfever generation
D0001774biological_processmicroglial cell activation
D0002024biological_processdiet induced thermogenesis
D0002790biological_processpeptide secretion
D0003085biological_processnegative regulation of systemic arterial blood pressure
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
D0005245molecular_functionvoltage-gated calcium channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006091biological_processgeneration of precursor metabolites and energy
D0006629biological_processlipid metabolic process
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007166biological_processcell surface receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007635biological_processchemosensory behavior
D0008218biological_processbioluminescence
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0009268biological_processresponse to pH
D0009408biological_processresponse to heat
D0009897cellular_componentexternal side of plasma membrane
D0010243biological_processresponse to organonitrogen compound
D0010459biological_processnegative regulation of heart rate
D0010917biological_processnegative regulation of mitochondrial membrane potential
D0014047biological_processglutamate secretion
D0014832biological_processurinary bladder smooth muscle contraction
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0017081molecular_functionchloride channel regulator activity
D0019233biological_processsensory perception of pain
D0019722biological_processcalcium-mediated signaling
D0030425cellular_componentdendrite
D0032591cellular_componentdendritic spine membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034605biological_processcellular response to heat
D0035091molecular_functionphosphatidylinositol binding
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043434biological_processresponse to peptide hormone
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0046872molecular_functionmetal ion binding
D0048265biological_processresponse to pain
D0048266biological_processbehavioral response to pain
D0050954biological_processsensory perception of mechanical stimulus
D0050955biological_processthermoception
D0050960biological_processdetection of temperature stimulus involved in thermoception
D0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
D0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
D0051219molecular_functionphosphoprotein binding
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0060079biological_processexcitatory postsynaptic potential
D0060083biological_processsmooth muscle contraction involved in micturition
D0070588biological_processcalcium ion transmembrane transport
D0071312biological_processcellular response to alkaloid
D0071318biological_processcellular response to ATP
D0071345biological_processcellular response to cytokine stimulus
D0071356biological_processcellular response to tumor necrosis factor
D0071363biological_processcellular response to growth factor stimulus
D0071468biological_processcellular response to acidic pH
D0071502biological_processcellular response to temperature stimulus
D0090212biological_processnegative regulation of establishment of blood-brain barrier
D0097603molecular_functiontemperature-gated ion channel activity
D0098703biological_processcalcium ion import across plasma membrane
D1901594biological_processresponse to capsazepine
D1990090biological_processcellular response to nerve growth factor stimulus
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues560
DetailsTRANSMEM: Helical => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
AILE434-TYR454
BGLU536-THR556
BMET572-ILE599
BVAL659-VAL687
CILE434-TYR454
CTYR472-LEU497
CTYR511-PHE531
CGLU536-THR556
CMET572-ILE599
CVAL659-VAL687
DILE434-TYR454
ATYR472-LEU497
DTYR472-LEU497
DTYR511-PHE531
DGLU536-THR556
DMET572-ILE599
DVAL659-VAL687
ATYR511-PHE531
AGLU536-THR556
AMET572-ILE599
AVAL659-VAL687
BILE434-TYR454
BTYR472-LEU497
BTYR511-PHE531

site_idSWS_FT_FI2
Number of Residues308
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
ATYR455-ASP471
DTYR455-ASP471
DSER532-LYS535
DGLU600-ALA658
ASER532-LYS535
AGLU600-ALA658
BTYR455-ASP471
BSER532-LYS535
BGLU600-ALA658
CTYR455-ASP471
CSER532-LYS535
CGLU600-ALA658

site_idSWS_FT_FI3
Number of Residues708
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
AGLN498-SER510
DGLN498-SER510
DARG557-LYS571
DASN688-LYS839
AARG557-LYS571
AASN688-LYS839
BGLN498-SER510
BARG557-LYS571
BASN688-LYS839
CGLN498-SER510
CARG557-LYS571
CASN688-LYS839

site_idSWS_FT_FI4
Number of Residues36
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
AARG116
BARG116
BLYS156
BLYS161
BASN165
BTYR200
BGLU211
BTYR511
BTHR550
BARG557
CARG116
ALYS156
CLYS156
CLYS161
CASN165
CTYR200
CGLU211
CTYR511
CTHR550
CARG557
DARG116
DLYS156
ALYS161
DLYS161
DASN165
DTYR200
DGLU211
DTYR511
DTHR550
DARG557
AASN165
ATYR200
AGLU211
ATYR511
ATHR550
AARG557

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9R186
ChainResidueDetails
AASP647
BASP647
CASP647
DASP647

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA and PKD => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
ASER117
BSER117
CSER117
DSER117

site_idSWS_FT_FI7
Number of Residues8
DetailsMOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
ATHR145
ATHR371
BTHR145
BTHR371
CTHR145
CTHR371
DTHR145
DTHR371

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
ASER502
BSER502
CSER502
DSER502

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
ATHR705
BTHR705
CTHR705
DTHR705

site_idSWS_FT_FI10
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
ASER775
ASER821
BSER775
BSER821
CSER775
CSER821
DSER775
DSER821

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC/PRKCE and PKC/PRKCZ => ECO:0000250|UniProtKB:O35433
ChainResidueDetails
ASER801
BSER801
CSER801
DSER801

site_idSWS_FT_FI12
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250
ChainResidueDetails
AASN604
BASN604
CASN604
DASN604

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