8GF2

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3

Summary for 8GF2

Entry DOI	10.2210/pdb8gf2/pdb
Descriptor	Spike protein S1, CC12.3 Fab heavy chain, CC12.3 Fab light chain, ... (7 entities in total)
Functional Keywords	antibody, sars-cov-2, sars-cov, coronavirus, spike, immune system, immune system-viral protein complex, immune system/viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	10
Total formula weight	242179.53
Authors	Yuan, M.,Zhu, X.,Wilson, I.A. (deposition date: 2023-03-07, release date: 2023-08-23)
Primary citation	Zhao, F.,Yuan, M.,Keating, C.,Shaabani, N.,Limbo, O.,Joyce, C.,Woehl, J.,Barman, S.,Burns, A.,Tran, Q.,Zhu, X.,Ricciardi, M.,Peng, L.,Smith, J.,Huang, D.,Briney, B.,Sok, D.,Nemazee, D.,Teijaro, J.R.,Wilson, I.A.,Burton, D.R.,Jardine, J.G. Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution. Sci.Signal., 16:eabk3516-eabk3516, 2023 Cited by PubMed: 37582161 DOI: 10.1126/scisignal.abk3516 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.851 Å)

Structure validation