8GF2

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (A, B)	Spike protein S1	polymer	231	26095.3	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2
2	B, G (C, E)	CC12.3 Fab heavy chain	polymer	220	23377.2	2		Homo sapiens (human)
3	C, H (D, F)	CC12.3 Fab light chain	polymer	215	23432.0	2		Homo sapiens (human)
4	D, I (H, X)	eCR3022.20 Fab heavy chain	polymer	222	23480.5	2		Homo sapiens (human)
5	E, J (L, Y)	eCR3022.20 Fab light chain	polymer	221	24382.0	2		Homo sapiens (human)
6	K (G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	L (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A, B: 319 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Ser 542	-	expression tag
Gly 543	-	expression tag
His 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	241533.9
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	242179.5

*Water molecules are not included.