8FUG
Alzheimer's disease paired-helical filament in complex with PET tracer GTP-1
Summary for 8FUG
Entry DOI | 10.2210/pdb8fug/pdb |
EMDB information | 29458 |
Descriptor | Microtubule-associated protein tau, (5S)-2-[4-(2-fluoroethyl)piperidin-1-yl]pyrimido[1,2-a]benzimidazole (2 entities in total) |
Functional Keywords | neurodegeneration, positron emission tomography, filament, alzheimer's disease, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 23 |
Total formula weight | 189485.48 |
Authors | Merz, G.E.,Tse, E.,Southworth, D.R. (deposition date: 2023-01-17, release date: 2023-06-07, Last modification date: 2024-06-19) |
Primary citation | Merz, G.E.,Chalkley, M.J.,Tan, S.K.,Tse, E.,Lee, J.,Prusiner, S.B.,Paras, N.A.,DeGrado, W.F.,Southworth, D.R. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nat Commun, 14:3048-3048, 2023 Cited by PubMed: 37236970DOI: 10.1038/s41467-023-38537-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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