8ESM
Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor
Summary for 8ESM
Entry DOI | 10.2210/pdb8esm/pdb |
EMDB information | 28577 |
Descriptor | Diacylglycerol O-acyltransferase 1, {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid (2 entities in total) |
Functional Keywords | triglyceride biosynthesis, lipid storage, lipid metabolism, membrane protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 111467.20 |
Authors | Sui, X.,Kun, W.,Walther, T.,Farese, R.,Liao, M. (deposition date: 2022-10-14, release date: 2023-06-07, Last modification date: 2024-06-19) |
Primary citation | Sui, X.,Wang, K.,Song, K.,Xu, C.,Song, J.,Lee, C.W.,Liao, M.,Farese Jr., R.V.,Walther, T.C. Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14:3100-3100, 2023 Cited by PubMed: 37248213DOI: 10.1038/s41467-023-38934-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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