8DFQ
Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers
Summary for 8DFQ
Entry DOI | 10.2210/pdb8dfq/pdb |
EMDB information | 27411 |
Descriptor | Isoform 2 of Mast/stem cell growth factor receptor Kit, Soluble KIT ligand, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | receptor tyrosine kinase, cell signaling, cancer, cryo-em, kit, stem cell factor, oncogenic mutant, extracellular domain, asymmetric interface, structural plasticity, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 254290.63 |
Authors | Krimmer, S.G.,Bertoletti, N.,Mi, W.,Schlessinger, J. (deposition date: 2022-06-22, release date: 2023-03-29, Last modification date: 2023-04-05) |
Primary citation | Krimmer, S.G.,Bertoletti, N.,Suzuki, Y.,Katic, L.,Mohanty, J.,Shu, S.,Lee, S.,Lax, I.,Mi, W.,Schlessinger, J. Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120:e2300054120-e2300054120, 2023 Cited by PubMed: 36943885DOI: 10.1073/pnas.2300054120 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.96 Å) |
Structure validation
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