8DFQ
Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 2 of Mast/stem cell growth factor receptor Kit | polymer | 978 | 110390.8 | 2 | UniProt (P10721) Pfam (PF00047) Pfam (PF07714) | Homo sapiens (human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | C, D (C, D) | Soluble KIT ligand | polymer | 141 | 16007.3 | 2 | UniProt (P21583) Pfam (PF02404) | Homo sapiens (human) | sKITLG |
| 3 | E, F, G (E, F, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 4 | H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A, B: 32 - 972 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Thr 2 | - | expression tag |
| Ile 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Cys 5 | - | expression tag |
| Trp 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Ala 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Leu 10 | - | expression tag |
| Ser 11 | - | expression tag |
| Thr 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Thr 14 | - | expression tag |
| Ala 15 | - | expression tag |
| Val 16 | - | expression tag |
| Asn 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Asp 19 | - | expression tag |
| Tyr 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Asp 22 | - | expression tag |
| Asp 23 | - | expression tag |
| Asp 24 | - | expression tag |
| Asp 25 | - | expression tag |
| Lys 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Pro 28 | - | expression tag |
| His 29 | - | expression tag |
| Ala 30 | - | expression tag |
| Met 31 | - | expression tag |
| Ile 417 | Thr 417 | engineered mutation |
| - | Tyr 418 | deletion |
| - | Asp 419 | deletion |
| Ala 619 | Lys 619 | engineered mutation |
| Gly 973 | - | expression tag |
| Ser 974 | - | expression tag |
| His 975 | - | expression tag |
| His 976 | - | expression tag |
| His 977 | - | expression tag |
| His 978 | - | expression tag |
| His 979 | - | expression tag |
| His 980 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 252796.2 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 254290.6 |
