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8DFQ

Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers

Functional Information from GO Data
ChainGOidnamespacecontents
A0001541biological_processovarian follicle development
A0001650cellular_componentfibrillar center
A0001669cellular_componentacrosomal vesicle
A0002020molecular_functionprotease binding
A0002244biological_processhematopoietic progenitor cell differentiation
A0002318biological_processmyeloid progenitor cell differentiation
A0002320biological_processlymphoid progenitor cell differentiation
A0002327biological_processimmature B cell differentiation
A0002551biological_processmast cell chemotaxis
A0002732biological_processpositive regulation of dendritic cell cytokine production
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
A0005020molecular_functionstem cell factor receptor activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0006468biological_processprotein phosphorylation
A0006687biological_processglycosphingolipid metabolic process
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
A0007283biological_processspermatogenesis
A0007286biological_processspermatid development
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0008354biological_processgerm cell migration
A0008360biological_processregulation of cell shape
A0008542biological_processvisual learning
A0008584biological_processmale gonad development
A0009314biological_processresponse to radiation
A0009897cellular_componentexternal side of plasma membrane
A0009898cellular_componentcytoplasmic side of plasma membrane
A0009986cellular_componentcell surface
A0010628biological_processpositive regulation of gene expression
A0010863biological_processobsolete positive regulation of phospholipase C activity
A0012501biological_processprogrammed cell death
A0016310biological_processphosphorylation
A0019221biological_processcytokine-mediated signaling pathway
A0019827biological_processstem cell population maintenance
A0019838molecular_functiongrowth factor binding
A0019955molecular_functioncytokine binding
A0030032biological_processlamellipodium assembly
A0030036biological_processactin cytoskeleton organization
A0030097biological_processhemopoiesis
A0030183biological_processB cell differentiation
A0030217biological_processT cell differentiation
A0030218biological_processerythrocyte differentiation
A0030318biological_processmelanocyte differentiation
A0030335biological_processpositive regulation of cell migration
A0031274biological_processpositive regulation of pseudopodium assembly
A0031401biological_processpositive regulation of protein modification process
A0032765biological_processpositive regulation of mast cell cytokine production
A0035019biological_processsomatic stem cell population maintenance
A0035162biological_processembryonic hemopoiesis
A0035234biological_processectopic germ cell programmed cell death
A0035556biological_processintracellular signal transduction
A0035701biological_processhematopoietic stem cell migration
A0035855biological_processmegakaryocyte development
A0038093biological_processFc receptor signaling pathway
A0038109biological_processKit signaling pathway
A0038162biological_processerythropoietin-mediated signaling pathway
A0042127biological_processregulation of cell population proliferation
A0042169molecular_functionSH2 domain binding
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042803molecular_functionprotein homodimerization activity
A0043069biological_processnegative regulation of programmed cell death
A0043235cellular_componentreceptor complex
A0043303biological_processmast cell degranulation
A0043410biological_processpositive regulation of MAPK cascade
A0043473biological_processpigmentation
A0043586biological_processtongue development
A0045747biological_processpositive regulation of Notch signaling pathway
A0045937biological_processpositive regulation of phosphate metabolic process
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046686biological_processresponse to cadmium ion
A0046777biological_processprotein autophosphorylation
A0046872molecular_functionmetal ion binding
A0048066biological_processdevelopmental pigmentation
A0048170biological_processpositive regulation of long-term neuronal synaptic plasticity
A0048565biological_processdigestive tract development
A0048863biological_processstem cell differentiation
A0050673biological_processepithelial cell proliferation
A0050910biological_processdetection of mechanical stimulus involved in sensory perception of sound
A0051091biological_processpositive regulation of DNA-binding transcription factor activity
A0051093biological_processnegative regulation of developmental process
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060326biological_processcell chemotaxis
A0060374biological_processmast cell differentiation
A0070662biological_processmast cell proliferation
A0070668biological_processpositive regulation of mast cell proliferation
A0097324biological_processmelanocyte migration
A0097326biological_processmelanocyte adhesion
A0120072biological_processpositive regulation of pyloric antrum smooth muscle contraction
A1904251biological_processregulation of bile acid metabolic process
A1904343biological_processpositive regulation of colon smooth muscle contraction
A1904349biological_processpositive regulation of small intestine smooth muscle contraction
A1905065biological_processpositive regulation of vascular associated smooth muscle cell differentiation
A2000242biological_processnegative regulation of reproductive process
B0001541biological_processovarian follicle development
B0001650cellular_componentfibrillar center
B0001669cellular_componentacrosomal vesicle
B0002020molecular_functionprotease binding
B0002244biological_processhematopoietic progenitor cell differentiation
B0002318biological_processmyeloid progenitor cell differentiation
B0002320biological_processlymphoid progenitor cell differentiation
B0002327biological_processimmature B cell differentiation
B0002551biological_processmast cell chemotaxis
B0002732biological_processpositive regulation of dendritic cell cytokine production
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
B0005020molecular_functionstem cell factor receptor activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0006468biological_processprotein phosphorylation
B0006687biological_processglycosphingolipid metabolic process
B0006954biological_processinflammatory response
B0007165biological_processsignal transduction
B0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
B0007283biological_processspermatogenesis
B0007286biological_processspermatid development
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0008354biological_processgerm cell migration
B0008360biological_processregulation of cell shape
B0008542biological_processvisual learning
B0008584biological_processmale gonad development
B0009314biological_processresponse to radiation
B0009897cellular_componentexternal side of plasma membrane
B0009898cellular_componentcytoplasmic side of plasma membrane
B0009986cellular_componentcell surface
B0010628biological_processpositive regulation of gene expression
B0010863biological_processobsolete positive regulation of phospholipase C activity
B0012501biological_processprogrammed cell death
B0016310biological_processphosphorylation
B0019221biological_processcytokine-mediated signaling pathway
B0019827biological_processstem cell population maintenance
B0019838molecular_functiongrowth factor binding
B0019955molecular_functioncytokine binding
B0030032biological_processlamellipodium assembly
B0030036biological_processactin cytoskeleton organization
B0030097biological_processhemopoiesis
B0030183biological_processB cell differentiation
B0030217biological_processT cell differentiation
B0030218biological_processerythrocyte differentiation
B0030318biological_processmelanocyte differentiation
B0030335biological_processpositive regulation of cell migration
B0031274biological_processpositive regulation of pseudopodium assembly
B0031401biological_processpositive regulation of protein modification process
B0032765biological_processpositive regulation of mast cell cytokine production
B0035019biological_processsomatic stem cell population maintenance
B0035162biological_processembryonic hemopoiesis
B0035234biological_processectopic germ cell programmed cell death
B0035556biological_processintracellular signal transduction
B0035701biological_processhematopoietic stem cell migration
B0035855biological_processmegakaryocyte development
B0038093biological_processFc receptor signaling pathway
B0038109biological_processKit signaling pathway
B0038162biological_processerythropoietin-mediated signaling pathway
B0042127biological_processregulation of cell population proliferation
B0042169molecular_functionSH2 domain binding
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0042803molecular_functionprotein homodimerization activity
B0043069biological_processnegative regulation of programmed cell death
B0043235cellular_componentreceptor complex
B0043303biological_processmast cell degranulation
B0043410biological_processpositive regulation of MAPK cascade
B0043473biological_processpigmentation
B0043586biological_processtongue development
B0045747biological_processpositive regulation of Notch signaling pathway
B0045937biological_processpositive regulation of phosphate metabolic process
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046686biological_processresponse to cadmium ion
B0046777biological_processprotein autophosphorylation
B0046872molecular_functionmetal ion binding
B0048066biological_processdevelopmental pigmentation
B0048170biological_processpositive regulation of long-term neuronal synaptic plasticity
B0048565biological_processdigestive tract development
B0048863biological_processstem cell differentiation
B0050673biological_processepithelial cell proliferation
B0050910biological_processdetection of mechanical stimulus involved in sensory perception of sound
B0051091biological_processpositive regulation of DNA-binding transcription factor activity
B0051093biological_processnegative regulation of developmental process
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0060326biological_processcell chemotaxis
B0060374biological_processmast cell differentiation
B0070662biological_processmast cell proliferation
B0070668biological_processpositive regulation of mast cell proliferation
B0097324biological_processmelanocyte migration
B0097326biological_processmelanocyte adhesion
B0120072biological_processpositive regulation of pyloric antrum smooth muscle contraction
B1904251biological_processregulation of bile acid metabolic process
B1904343biological_processpositive regulation of colon smooth muscle contraction
B1904349biological_processpositive regulation of small intestine smooth muscle contraction
B1905065biological_processpositive regulation of vascular associated smooth muscle cell differentiation
B2000242biological_processnegative regulation of reproductive process
C0005173molecular_functionstem cell factor receptor binding
C0007155biological_processcell adhesion
C0016020cellular_componentmembrane
D0005173molecular_functionstem cell factor receptor binding
D0007155biological_processcell adhesion
D0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNILL
ChainResidueDetails
ACYS784-LEU796

site_idPS00240
Number of Residues14
DetailsRECEPTOR_TYR_KIN_III Receptor tyrosine kinase class III signature. GnHmNIVNLLGACT
ChainResidueDetails
AGLY644-THR657

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Not glycosylated
ChainResidueDetails
CASN72
DASN72

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:1381905
ChainResidueDetails
CASN65
CASN93
DASN65
DASN93

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1381905
ChainResidueDetails
CASN120
BALA625
BASP673
BHIS798
BGLY799
BASP812
DASN120
AALA625
AASP673
AHIS798
AGLY799
AASP812
BTHR570
BLYS598

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for interaction with phosphotyrosine-binding proteins
ChainResidueDetails
ACYS938
BCYS938

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:20147452
ChainResidueDetails
ATYR549
AVAL555
AALA732
BTYR549
BVAL555
BALA732

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12824176, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21030588, ECO:0000269|PubMed:9038210
ChainResidueDetails
ATHR570
BTHR570

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12824176, ECO:0000269|PubMed:9038210
ChainResidueDetails
ALEU572
BLEU572

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:10377264, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:20147452
ChainResidueDetails
ASER705
BSER705

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:20147452, ECO:0000269|PubMed:9038210
ChainResidueDetails
AGLY723
BGLY723

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC/PRKCA => ECO:0000269|PubMed:7539802
ChainResidueDetails
ATYR743
AVAL748
BTYR743
BVAL748

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:7539802
ChainResidueDetails
AGLY823
BGLY823

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:20147452
ChainResidueDetails
AALA825
BALA825

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12878163
ChainResidueDetails
AALA893
BALA893

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:20147452
ChainResidueDetails
ACYS902
BCYS902

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:10377264, ECO:0000269|PubMed:19265199
ChainResidueDetails
ACYS938
BCYS938

site_idSWS_FT_FI16
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:7539802, ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER961
BSER961

site_idSWS_FT_FI17
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17662946
ChainResidueDetails
AASN130
BASN130

site_idSWS_FT_FI18
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN145
ASER465
ATHR488
BASN145
BSER465
BTHR488

site_idSWS_FT_FI19
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
ChainResidueDetails
AASN283
BASN320
BASN352
BASN367
AASN293
AASN300
AASN320
AASN352
AASN367
BASN283
BASN293
BASN300

224004

PDB entries from 2024-08-21

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