8D74
Cryo-EM structure of human CNTF signaling complex: model containing the interaction core region
Summary for 8D74
Entry DOI | 10.2210/pdb8d74/pdb |
EMDB information | 27227 |
Descriptor | Interleukin-6 receptor subunit beta, Ciliary neurotrophic factor, Ciliary neurotrophic factor receptor subunit alpha, ... (6 entities in total) |
Functional Keywords | cytokine signaling, cntf, cntfr alpha, gp130, lifr, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 228501.83 |
Authors | |
Primary citation | Zhou, Y.,Stevis, P.E.,Cao, J.,Saotome, K.,Wu, J.,Glatman Zaretsky, A.,Haxhinasto, S.,Yancopoulos, G.D.,Murphy, A.J.,Sleeman, M.W.,Olson, W.C.,Franklin, M.C. Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9:eade4395-eade4395, 2023 Cited by PubMed: 36930708DOI: 10.1126/sciadv.ade4395 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.03 Å) |
Structure validation
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