8CN9

Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII

Summary for 8CN9

Entry DOI	10.2210/pdb8cn9/pdb
Descriptor	Fab light chain, Fab heavy chain, Coagulation factor VII, ... (8 entities in total)
Functional Keywords	factor vii, fab, bispecific antibody, hmb-001, blood clotting
Biological source	Homo sapiens More
Total number of polymer chains	20
Total formula weight	446753.59
Authors	Schluckebier, G.,Johansson, E. (deposition date: 2023-02-22, release date: 2023-12-27, Last modification date: 2024-09-11)
Primary citation	Gandhi, P.S.,Zivkovic, M.,Ostergaard, H.,Bonde, A.C.,Elm, T.,Lovgreen, M.N.,Schluckebier, G.,Johansson, E.,Olsen, O.H.,Olsen, E.H.N.,de Bus, I.A.,Bloem, K.,Alskar, O.,Rea, C.J.,Bjorn, S.E.,Schutgens, R.E.,Sorensen, B.,Urbanus, R.T.,Faber, J.H. A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders. Nat Cardiovasc Res, 3:166-185, 2024 Cited by PubMed: 39196196 DOI: 10.1038/s44161-023-00418-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation