8CN9

Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0005509	molecular_function	calcium ion binding
E	0007596	biological_process	blood coagulation
E	0016020	cellular_component	membrane
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis
I	0005509	molecular_function	calcium ion binding
J	0007596	biological_process	blood coagulation
J	0016020	cellular_component	membrane
M	0004252	molecular_function	serine-type endopeptidase activity
M	0006508	biological_process	proteolysis
N	0005509	molecular_function	calcium ion binding
O	0007596	biological_process	blood coagulation
O	0016020	cellular_component	membrane
R	0004252	molecular_function	serine-type endopeptidase activity
R	0006508	biological_process	proteolysis
S	0005509	molecular_function	calcium ion binding
T	0007596	biological_process	blood coagulation
T	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDqlqsYiCfC

Chain	Residue	Details
D	CYS61-CYS72

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CfClpAfeGRnC

Chain	Residue	Details
D	CYS70-CYS81

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site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
C	VAL189-CYS194

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
C	ASP338-ALA349

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
A	TYR192-HIS198
B	TYR203-HIS209

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site_id	PS00621
Number of Residues	18
Details	TISSUE_FACTOR Tissue factor signature. WKsKCfyTtDTECDLTDE

Chain	Residue	Details
E	TRP45-GLU62

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site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
D	CYS112-CYS127

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site_id	PS01187
Number of Residues	25
Details	EGF_CA Calcium-binding EGF-like domain signature. DgDQCassp..........Cqnggs..CkDqlqsYiC

Chain	Residue	Details
D	ASP46-CYS70

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	872
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
E	SER1-GLU219
R	HIS193
R	ASP242
R	SER344
J	SER1-GLU219
O	SER1-GLU219
T	SER1-GLU219
H	ASP242
H	SER344
M	HIS193
M	ASP242
M	SER344

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site_id	SWS_FT_FI2
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN124
E	ASN137
J	ASN124
J	ASN137
O	ASN124
O	ASN137
T	ASN124
T	ASN137

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: (3R)-3-hydroxyaspartate => ECO:0000269|PubMed:3264725

Chain	Residue	Details
D	ASP63
I	ASP63
N	ASP63
S	ASP63

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (Xyl...) serine; alternate => ECO:0000269|PubMed:1904059, ECO:0000269|PubMed:2129367, ECO:0000269|PubMed:21949356, ECO:0000269|PubMed:2511201

Chain	Residue	Details
D	SER52
I	SER52
N	SER52
S	SER52

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site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: O-linked (Fuc) serine => ECO:0000269|PubMed:1904059, ECO:0000269|PubMed:9023546

Chain	Residue	Details
D	SER60
I	SER60
N	SER60
S	SER60

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725

Chain	Residue	Details
D	ASN145
I	ASN145
N	ASN145
S	ASN145

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