8CAA
Crystal structure of TEAD4 in complex with YTP-13
Summary for 8CAA
Entry DOI | 10.2210/pdb8caa/pdb |
Descriptor | Transcriptional enhancer factor TEF-3, 4-[bis(fluoranyl)methoxy]-2-[(2~{S})-5-chloranyl-6-fluoranyl-2-[[(4-oxidanylcyclohexyl)amino]methyl]-2-phenyl-3~{H}-1-benzofuran-4-yl]-3-fluoranyl-benzamide, (2~{R})-2-[2-chloranyl-5-[2-chloranyl-4-(trifluoromethyl)phenoxy]phenyl]sulfanylpropanoic acid, ... (5 entities in total) |
Functional Keywords | complex, inhibitor, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 53271.06 |
Authors | Scheufler, C.,Kallen, J. (deposition date: 2023-01-24, release date: 2023-04-12, Last modification date: 2024-06-19) |
Primary citation | Sellner, H.,Chapeau, E.,Furet, P.,Voegtle, M.,Salem, B.,Le Douget, M.,Bordas, V.,Groell, J.M.,Le Goff, A.L.,Rouzet, C.,Wietlisbach, T.,Zimmermann, T.,McKenna, J.,Brocklehurst, C.E.,Chene, P.,Wartmann, M.,Scheufler, C.,Kallen, J.,Williams, G.,Harlfinger, S.,Traebert, M.,Dumotier, B.M.,Schmelzle, T.,Soldermann, N. Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors. Chemmedchem, 18:e202300051-e202300051, 2023 Cited by PubMed: 36988034DOI: 10.1002/cmdc.202300051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.999 Å) |
Structure validation
Download full validation report