8BFF

Human PPARgamma in complex with MINCH bound to the AF-2 sub-pocket

Summary for 8BFF

Entry DOI	10.2210/pdb8bff/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (1~{S},2~{R})-2-[(4~{R})-4-methylheptoxy]carbonylcyclohexane-1-carboxylic acid (3 entities in total)
Functional Keywords	ppar gamma activation, minch, ligand binding domain, environmental contaminant, nuclear protein
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	97522.12
Authors	Useini, A.,Straeter, N. (deposition date: 2022-10-25, release date: 2023-03-08, Last modification date: 2024-02-07)
Primary citation	Useini, A.,Engelberger, F.,Kunze, G.,Strater, N. Structural basis of the activation of PPAR gamma by the plasticizer metabolites MEHP and MINCH. Environ Int, 173:107822-107822, 2023 Cited by PubMed: 36841188 DOI: 10.1016/j.envint.2023.107822 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation