8A64
cryoEM structure of the catalytically inactive EndoS from S. pyogenes in complex with the Fc region of immunoglobulin G1.
This is a non-PDB format compatible entry.
Summary for 8A64
Entry DOI | 10.2210/pdb8a64/pdb |
EMDB information | 15205 |
Descriptor | Endo-beta-N-acetylglucosaminidase F2, Immunoglobulin gamma-1 heavy chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | endoglycosidase s, endos, endo-b-n-acetylglucosaminidase, fc region, antibody, immunoglobulin g1, streptococcus pyogenes, n-glycans, hydrolase |
Biological source | Streptococcus pyogenes More |
Total number of polymer chains | 3 |
Total formula weight | 207656.86 |
Authors | Trastoy, B.,Cifuente, J.O.,Du, J.J.,Sundberg, E.J.,Guerin, M.E. (deposition date: 2022-06-16, release date: 2023-04-05, Last modification date: 2023-07-26) |
Primary citation | Trastoy, B.,Du, J.J.,Cifuente, J.O.,Rudolph, L.,Garcia-Alija, M.,Klontz, E.H.,Deredge, D.,Sultana, N.,Huynh, C.G.,Flowers, M.W.,Li, C.,Sastre, D.E.,Wang, L.X.,Corzana, F.,Mallagaray, A.,Sundberg, E.J.,Guerin, M.E. Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases. Nat Commun, 14:1705-1705, 2023 Cited by PubMed: 36973249DOI: 10.1038/s41467-023-37215-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.6 Å) |
Structure validation
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