7ZSQ
human purine nucleoside phosphorylase in complex with JS-555
Summary for 7ZSQ
Entry DOI | 10.2210/pdb7zsq/pdb |
Descriptor | Purine nucleoside phosphorylase, [2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenoxy]methylphosphonic acid, 6-tungstotellurate(VI), ... (8 entities in total) |
Functional Keywords | pnp-inhibitor complex, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 3 |
Total formula weight | 86771.33 |
Authors | Djukic, S.,Pachl, P.,Rezacova, P. (deposition date: 2022-05-08, release date: 2023-05-17, Last modification date: 2024-02-07) |
Primary citation | Skacel, J.,Djukic, S.,Baszczynski, O.,Kalcic, F.,Bilek, T.,Chalupsky, K.,Kozak, J.,Dvorakova, A.,Tloust'ova, E.,Kral'ova, Z.,Smidkova, M.,Voldrich, J.,Rumlova, M.,Pachl, P.,Brynda, J.,Vuckova, T.,Fabry, M.,Snasel, J.,Pichova, I.,Rezacova, P.,Mertlikova-Kaiserova, H.,Janeba, Z. Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. J.Med.Chem., 66:6652-6681, 2023 Cited by PubMed: 37134237DOI: 10.1021/acs.jmedchem.2c02097 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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