7ZL3
Signal peptide mimicry primes Sec61 for client-selective inhibition
Summary for 7ZL3
Entry DOI | 10.2210/pdb7zl3/pdb |
EMDB information | 14776 3068 |
Descriptor | Protein transport protein Sec61 subunit alpha, Protein transport protein Sec61 subunit gamma, Protein transport protein Sec61 subunit beta, ... (4 entities in total) |
Functional Keywords | sec61 translocon, cryoem, membrane protein, protein biogenesis |
Biological source | Ovis aries (sheep) More |
Total number of polymer chains | 4 |
Total formula weight | 63374.41 |
Authors | Rehan, S.,Paavilainen O, V. (deposition date: 2022-04-13, release date: 2023-03-22, Last modification date: 2023-11-15) |
Primary citation | Rehan, S.,Tranter, D.,Sharp, P.P.,Craven, G.B.,Lowe, E.,Anderl, J.L.,Muchamuel, T.,Abrishami, V.,Kuivanen, S.,Wenzell, N.A.,Jennings, A.,Kalyanaraman, C.,Strandin, T.,Javanainen, M.,Vapalahti, O.,Jacobson, M.P.,McMinn, D.,Kirk, C.J.,Huiskonen, J.T.,Taunton, J.,Paavilainen, V.O. Signal peptide mimicry primes Sec61 for client-selective inhibition. Nat.Chem.Biol., 19:1054-1062, 2023 Cited by PubMed: 37169961DOI: 10.1038/s41589-023-01326-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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