7ZDD

Crystal structure of TRIM33 PHD-Bromodomain isoform B in complex with H3K10ac histone peptide.

Summary for 7ZDD

• Entry DOI: 10.2210/pdb7zdd/pdb
• Related: 5MR8
• Descriptor: E3 ubiquitin-protein ligase TRIM33, Histone H3.X, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: e3 ubiquitin-protein ligase, acetylation, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 23828.29

Authors

Caria, S.,Duclos, S.,Crespillo, S.,Errey, J.,Barker, J.J. (deposition date: 2022-03-29, release date: 2022-06-29, Last modification date: 2024-01-31)

• Primary citation: Sekirnik, A.R.,Reynolds, J.K.,See, L.,Bluck, J.P.,Scorah, A.R.,Tallant, C.,Lee, B.,Leszczynska, K.B.,Grimley, R.L.,Storer, R.I.,Malattia, M.,Crespillo, S.,Caria, S.,Duclos, S.,Hammond, E.M.,Knapp, S.,Morris, G.M.,Duarte, F.,Biggin, P.C.,Conway, S.J.; Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33 alpha and TRIM33 beta Bromodomains.; Acs Chem.Biol., 17:2753-2768, 2022; PubMed: 36098557; DOI: 10.1021/acschembio.2c00266

Experimental method

X-RAY DIFFRACTION (1.625 Å)